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Nutritional status assessment in patients with hepatopathy
Pirklová, Kristýna ; Novák, František (advisor) ; Ševela, Stanislav (referee)
In patients with liver cirrhosis, a high prevalence of malnutrition should be expected. Although the early diagnosis of malnutrition and well-chosen nutritional support have a positive effect on the patient's prognosis, early diagnosis of malnutrition might be difficult. There is currently no standardized diagnostic protocol for the nutritional status assessment of patients with liver cirrhosis. In patients with liver cirrhosis fluid retention occurs, which distorts the otherwise commonly used diagnostic criteria. The aim of the study: We wanted to evaluate the nutritional status of patients with liver cirrhosis in comparison with a acontrol group without severe comorbidity using anthropometric measurements, electrical bioimpedance, functional tests and laboratory parameters using diagnostic criteria GLIM (Global Leadership Initiative On Malnutrition) and various malnutrition screening tools. The work also focused on evaluating the quality of life of patients with chronic liver disease. Methods: The observational study included 11 patients with Child-Pugh stage cirrhosis A (n = 10) and B (n = 1), who were compared with a control group of 11 study participants without severe comorbidities. An examination panel consisting of anthropometric measurements, indirect calorimetry, electrical bioimpedance,...
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Functional fitness and Vit. D levels in patients with hepatopathy
Brtková, Helena ; Novák, František (advisor) ; Meisnerová, Eva (referee)
Introduction: patients with hepatopathy are at risk of vitamin D deficiency. Vitamin D levels affect, among other things, metabolism and physiological functions of muscle tissue and thus functional fitness. The aim of this study is to assess muscle mass and strength in relation to vitamin D levels and other factors that affect functional physical fitness in patients with cirrhosis, compared to a control group of patients without hepatopathy and other chronic comorbidities. Methods: 11 patients with liver cirrhosis were enrolled in an observational cohort study compared with 11 controls without chronic comorbidities. Anthropometric and bioimpedance measurements were performed, functional tests, the 6MWT 6-minute walk test, hand grip strength assessment and calorimetry examination were also evaluated, and laboratory parameters were assessed. Study participants completed the CLDQ test, which assessed the quality of life of people with liver disease. Respondents answered questions regarding lifestyle, eating habits, physical activity and functional physical fitness. For patients with cirrhosis, the Child Pugh score and MELD score were used to assess the progression of cirrhosis. Results. At the time of the study, the vast majority of patients had a compensated form of liver cirrhosis, Child Pugh A...
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